If its search indexing...

(1) Open the "Indexing Options" applet in the Control Panel and:
(2) Click the "Advanced" tab
(3) Click on "File Types" and select/deselect indexing services or Click
"Modify" to include/exclude folder indexing.

shamelessly ripped from someplace that i cant remember.

Additionally... Vista x64 rocks. Can't really speak to x86, since I haven't ever used it.